The one that is not about heat: an open beak when it is not hot and she has not just been chased. With wheezing, gurgling or rattling, sneezing, nasal discharge, swollen or bubbly eyes, coughing, head shaking, or sitting fluffed and off her food.
Separate her and ring somebody, because respiratory disease moves through a flock. A bit of panting after being handled that stops within a minute or two is nothing at all.